Probiotics: A Promising Shield against PFAS-Induced Gut Toxicity
DOI:
https://doi.org/10.64261/42za9a22Keywords:
PFAS (Per- and polyfluoroalkyl substances), Forever chemicals, Environmental persistence, Human health impacts, Bioaccumulation, Toxic legacyAbstract
PFAS are a huge family of enduring synthetic chemicals commonly present in industrial and consumer goods because of their hydrophobic and oleophobic characteristics. They have caused significant health concerns to the people around the world because of their environmental stability and bioaccumulation capacity, which has resulted in contamination of water, soil, wildlife and human beings. PFAS has been linked to several negative effects in the event of chronic exposure, such as liver damage, thyroid dysfunction, immunotoxicity, developmental abnormalities, and heightened risks of cancer. Recent studies show that probiotics are an exciting gut-based treatment to counteract PFAS toxicity. Certain strains of Lactobacillus and Bifidobacterium can lower the absorption of PFAS by binding to the gastrointestinal tract, repairing intestinal barrier function, altering bile acid metabolism, and possibly biotransforming it. The preclinical evidence indicates that probiotics may help to reduce the inflammation caused by PFAS and improve the toxin excretion, yet the evidence is mostly animal-based. Major gaps are present such as the absence of adequate human clinical testing, incorrect dosage, and variation in efficacy by strain. Although probiotics are a natural and inexpensive adjunct method, their combination into PFAS mitigation strategies is still to be validated. To effectively control the exposure of PFAS and related health hazards, the use of a multidisciplinary method that incorporates scientific studies, regulatory intervention, and community education is necessary.
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