Quercetin and Cancer: Investigating Therapeutic Benefits of Neem-Derived Flavonoids
DOI:
https://doi.org/10.64261/8y9rwc76Keywords:
Azadirachta indica, Apoptosis, Cancer therapy, Quercetin, clinical trialsAbstract
Quercetin, a flavonoid compound isolated from Azadirachta indica (neem), has gained significant attention in recent research for its potential as an anti-cancer agent. Neem, widely used in traditional medicine, contains a variety of bioactive compounds, with quercetin being one of the most studied for its therapeutic properties. Quercetin possesses promising anticancer effects, including the ability to inhibit cancer cell growth, induce apoptosis (programmed cell death), and regulate immune responses. Additionally, quercetin has been found to inhibit angiogenesis, the process by which tumors form new blood vessels to sustain their growth. These properties highlight quercetin's dual role as both a direct anti-cancer agent and an immune system modulator, positioning it as a potential natural therapeutic in cancer treatment. Quercetin's ability to target multiple stages of cancer progression, including cell proliferation, metastasis, and tumor growth, makes it an attractive candidate for further investigation. While preclinical studies have shown encouraging results, the translation of these findings to clinical applications remains a critical step. Further clinical trials are necessary to determine the efficacy, safety, and optimal dosage of quercetin in human cancer treatment. This review summarizes the current understanding of quercetin's anticancer properties, explores its mechanisms of action, and discusses its potential as a therapeutic agent in cancer therapy, highlighting the need for continued research in this promising area.
References
1. Sharma A, Paliwal M. An analysis of several medical properties of neem. Asian Journal of Research in Social Sciences and Humanities 11(11), 785-791 (2021).
2. Jadhav VP, Suryawanshi YR, Parameswaran S, Wankhede NN. Unveiling the therapeutic potential of neem flower: a phytochemical study for antidiabetic and anticancer properties. Natural Product Research doi:10.1080/14786419.2024.2433194 1-17
3. Haji AS, Maurya SR, Shah N. Azadirachta indica A. Juss.: ethnobotanical knowledge, phytochemical studies, pharmacological aspects future prospects. Plant Environ 5(1), 1-15 (2023).
4. Mehnaz S, Shamsi Y, Akhtar MW, Mohanty S, Ahmad S. Therapeutic Applications of Neem (Azadirachta indica): A Narrative Review. Adv Mind Body Med 38(4), 14-18 (2024).
5. Kadir A, Ghosh T, Ilango K et al. In-depth review on taxonomy, phytochemistry, traditional uses and pharmacological significance of Azadirachta indica plant. European Journal of Biomedical 11(6), 277-284 (2024).
6. Pal D, Sahu P, Sinha P, Dewangan P. Neem (Azadirachta indica) and Hibiscus Seed as Antiproliferative Agents. In: Seeds: Anti-proliferative Storehouse for Bioactive Secondary Metabolites, Pal D (Ed.^(Eds).Springer Nature Singapore Singapore 785-810 (2024).
7. Sarkar S, Singh RP, Bhattacharya G. Exploring the role of Azadirachta indica (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach. 3 Biotech 11(4), 178 (2021).
8. Maji S, Modak S. Neem: Treasure of natural phytochemicals. Chem Sci Rev Lett 10(39), 396-401 (2021).
9. Yuan L, Cai Y, Zhang L, Liu S, Li P, Li X. Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review. Frontiers in Pharmacology 12 (2022).
10. Kim W, Park S, Han S-H et al. PRPF4 Knockdown Suppresses Glioblastoma Progression <em>via</em> the p38 MAPK and ERK Signaling Pathways. Anticancer Research 45(2), 549 (2025).
11. Veisaga ML, Ahumada M, Soriano S et al. Anti-proliferative effect of Annona extracts on breast cancer cells. Biocell 47(8), 1835-1852 (2023).
12. Zhang J, Wu Y, Li Y et al. Natural products and derivatives for breast cancer treatment: From drug discovery to molecular mechanism. Phytomedicine 129 155600 (2024).
13. Yang L, Ma H. Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation. Journal of Functional Foods 125 106657 (2025).
14. Chai R, Xu C, Lu L, Liu X, Ma Z. Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway. Immunopharmacology and Immunotoxicology 43(6), 693-703 (2021).
15. Li Y, Yao J, Han C et al. Quercetin, Inflammation and Immunity. Nutrients 8(3), 167 (2016).
16. Haleagrahara N, Hodgson K, Miranda-Hernandez S, Hughes S, Kulur AB, Ketheesan N. Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis. Inflammopharmacology 26(5), 1219-1232 (2018).
17. Yang D, Dang S, Wang Z, Xie M, Li X, Ding X. Vessel co-option: a unique vascular-immune niche in liver cancer. Frontiers in Oncology 14 1386772 (2024).
18. Oh SJ, Kim O, Lee JS et al. Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food and Chemical Toxicology 48(11), 3227-3234 (2010).
19. Shahbaz M, Naeem H, Momal U et al. Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies. International Journal of Food Properties 26(1), 2590-2626 (2023).
20. Dhanaraj T, Mohan M, Arunakaran J. Quercetin attenuates metastatic ability of human metastatic ovarian cancer cells via modulating multiple signaling molecules involved in cell survival, proliferation, migration and adhesion. Archives of Biochemistry and Biophysics 701 108795 (2021).
21. Lei C-S, Hou Y-C, Pai M-H, Lin M-T, Yeh S-L. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. The Journal of Nutritional Biochemistry 51 105-113 (2018).
22. Granado-Serrano AB, Martiín MA, Bravo L, Goya L, Ramos S. Quercetin Induces Apoptosis via Caspase Activation, Regulation of Bcl-2, and Inhibition of PI-3-Kinase/Akt and ERK Pathways in a Human Hepatoma Cell Line (HepG2)1. The Journal of Nutrition 136(11), 2715-2721 (2006).
23. Mutlu Altundağ E, Kasacı T, Yılmaz AM et al. Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells. Journal of Thyroid Research 2016(1), 9843675 (2016).
24. Xu D, Hu MJ, Wang YQ, Cui YL. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules 24(6), (2019).
25. Yisha T. Study on the anti-tumor effects of the key component of traditional Chinese medicine nightshade in the treatment of human gastric cancer (SGC7901 cell line). Presented at: Proc.SPIE. 2023.
26. Huang J, Chen J, Li J. Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer. Journal of Molecular Histology 55(2), 211-225 (2024).
27. Shi X-F, Yu Q, Wang K-B et al. Active ingredients Isorhamnetin of Croci Srigma inhibit stomach adenocarcinomas progression by MAPK/mTOR signaling pathway. Scientific Reports 13(1), 12607 (2023).
28. Feng SH, Zhao B, Zhan X et al. Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation. Am J Cancer Res 14(3), 934-958 (2024).
29. Tang Z, Wang L, Chen Y et al. Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway. Eur J Histochem 67(3), (2023).
30. Trinh N-T, Nguyen TMN, Yook J-I, Ahn S-G, Kim S-A. Quercetin and Quercitrin from Agrimonia pilosa Ledeb Inhibit the Migration and Invasion of Colon Cancer Cells through the JNK Signaling Pathway. Pharmaceuticals 15(3), 364 (2022).
31. Panthi VK, Dua K, Singh SK, Gupta G, Hansbro PM, Paudel KR. Nanoformulations-Based Metronomic Chemotherapy: Mechanism, Challenges, Recent Advances, and Future Perspectives. Pharmaceutics 15(4), 1192 (2023).
32. Haddad R, Alrabadi N, Altaani B, Li T. Paclitaxel Drug Delivery Systems: Focus on Nanocrystals’ Surface Modifications. Polymers 14(4), 658 (2022).
33. Almatroodi, S. A., Alsahli, M. A., Almatroudi, A., Verma, A. K., Aloliqi, A., Allemailem, K. S., ... & Rahmani, A. H. (2021). Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules, 26(5), 1315.
34. Biswas, P., Dey, D., Biswas, P. K., Rahaman, T. I., Saha, S., Parvez, A., ... & Kim, B. (2022). A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells. International journal of molecular sciences, 23(19), 11746.
35. Mehta, P. A., Nelson, A., Loveless, S., Lane, A., Fukuda, T., Teusink-Cross, A., ... & Davies, S. M. (2025). Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood Advances, 9(8), 1927-1939.
36. Belfiore, E., Di Prima, G., Angellotti, G., Panzarella, V., & De Caro, V. (2024). Plant-derived polyphenols to prevent and treat oral mucositis induced by chemo-and radiotherapy in head and neck cancers management. Cancers, 16(2), 260.
37. Stewart, K. L., & Lephart, E. D. (2023). Overview of BPH: symptom relief with dietary polyphenols, vitamins and phytochemicals by nutraceutical supplements with implications to the prostate microbiome. International Journal of Molecular Sciences, 24(6), 5486.
38. Lee, G. H., Taritsa, I. C., Ruiz, E. S., & LeBoeuf, N. R. (2025). Squamous cell carcinoma. In Mohs Micrographic Surgery (pp. 229-254). Cham: Springer Nature Switzerland.
39. Vyas, J., Raytthatha, N., Prajapati, B. G., & Singh, S. (2025). Polymeric Molecular Envelope Technology for Improved Therapeutics Efficacy: A Review. Current Medicinal Chemistry, 32(21), 4176-4191.
40. Khamineh, Y., Ghiasvand, M., Panahi-Alanagh, S., Rastegarmand, P., Zolghadri, S., & Stanek, A. (2025). A Narrative Review of Quercetin’s Role as a Bioactive Compound in Female Reproductive Disorders. Nutrients, 17(7), 1118.
41. Mohamed Elmokadem, E., Khaled Abou El Fadl, D., Bassiouny, A. M., Mahmoud, M. M. A. E., Samy, M., & El Said, N. O. (2025). The Adjunctive Effect of Quercetin on Postoperative Pain Management Following Cesarean Section: A Randomized Controlled Study. Drug Design, Development and Therapy, 6009-6024.
42. Sirhan, Z., Abu Nada, A., Anabtawi, N., Thyagarajan, A., & Sahu, R. P. (2025). Metformin-based combination approaches for triple-negative breast cancer. Pharmaceutics, 17(5), 558.
43. Nambiar, A., Kellogg, D., Justice, J., Goros, M., Gelfond, J., Pascual, R., ... & Kirkland, J. (2023). Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine, 90.
44. Wang, Z., Liu, Z., Qu, J., Sun, Y., & Zhou, W. (2024). Role of natural products in tumor therapy from basic research and clinical perspectives. Acta Materia Medica, 3(2), 163-206.
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