Nanosponges: An Emerging Platform for Drug Delivery
Article Sidebar
Main Article Content
Abstract
Achieving effective targeted drug delivery systems has been an aspiration for quite some time, but this goal has often been hindered by the intricate chemistry involved in creating new systems. The development of nano sponges represents a significant advancement in addressing these challenges. Nanosponges are minuscule sponges comparable in size to a virus, capable of containing a diverse range of drugs. Traditional topical drug delivery systems encounter numerous issues such as limited permeability, skin irritation, and allergic reactions. The newly developed colloidal system known as nanosponges has the potential to mitigate these concerns. These tiny sponges, measuring between 250 nm to 1 μm, have cavities that can be filled with various drugs. They improve solubility, enhance bioavailability, decrease side effects, and alter drug release. The nanosponges drug delivery system has surfaced as one of the most promising areas within pharmaceutics.
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
All articles published in the Pan-African Journal of Health and Psychological Sciences (PAJHPS) are open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0).
Under this license:
-
Authors retain copyright and grant the journal the right of first publication.
-
The work may be shared, copied, redistributed, and adapted for any purpose, even commercially.
-
Appropriate credit must be given to the original author(s) and the journal, along with a link to the license.
-
Users must indicate if changes were made.
-
There are no restrictions on reuse, provided the original work is properly cited.
Citation:
Authors and users must cite the original work in the following manner:
Author(s). (Year). Title of the article. Pan-African Journal of Health and Psychological Sciences, Volume(Issue), page range. https://doi.org/xx.xxxx/pajhps.vXnY.xxx
Copyright Statement:
Authors grant PAJHPS a non-exclusive license to publish the work and identify itself as the original publisher. Authors may enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version (e.g., post it to a repository or publish it in a book), with acknowledgment of its initial publication in this journal.
How to Cite
References
1. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges. EP 1 786 841 B1; 2007.
2. Kumari P, Upadhyay NK, Varma R, Kumar S, Gharti L, Kaurav H. Formulation and evaluation of famotidine-loaded nanosponges for the treatment of peptic ulcer: and evaluation in vivo in vitro. Journal of Applied Pharmaceutical Science. 2025;15(3):260-269. DOI: 10.7324/JAPS.2025.215406.
3. David F. Nanosponge drug delivery system more effective than direct injection. www.physorg.com 01.06.2010, accessed on 20.12.2011
4. Vyas A, Saraf S, Saraf S. Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem 2008;62:23-42.[Crossref] [Google Scholar]
5. Tiwari H, Mahor A, Dixit ND, Kushwaha M. A review on nanosponges. World J Pharm Sci 2014;3:219-33.
6. Kumar S, Rao R. Analytical tools for cyclodextrin nanosponges in pharmaceutical field: A review. J Inclusion Phenomena Macrocyclic Chem 2019;94:11-30. [Crossref] [Google Scholar]
7. Darandale SS, Vavia PR. Cyclodextrin-based nanosponges of curcumin: Formulation and physicochemical characterization. J Incl Phenom Macrocycl Chem 2013;75:315-22.[Crossref] [Google Scholar]
8. Utzeri G, Matias PM, Murtinho D, Valente AJ. Cyclodextrin-based nanosponges: Overview and opportunities. Front chEm 2022;10:859406. [Crossref] [Google Scholar]
9. Kumari P, Upadhyay NK, Varma R, Kumar S, Gharti L, Kaurav H. Formulation and evaluation of famotidine-loaded nanosponges for the treatment of peptic ulcer: and evaluation in vivo in vitro. Journal of Applied Pharmaceutical Science. 2025;15(3):260-269. DOI: 10.7324/JAPS.2025.215406.
10. Gilardi G, Trota F, Cavalli R, Ferruti P, Ranucci E, Di Nardo G, Roggero C, Tumiatti V. Cyclodextrin nanosponges as carrier for biocatalysts, and in the delivery and release of enzymes, proteins, vaccines and antibodies. WO2009149883 A1; 2009.
11. Lala R, Thorat A, Gargote C. Current trends in β cyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526.
12. Trotta F, Tumiatti V, Cavalli R, Roggero C, Mognetti R and Berta G,2009. “Cyclodextrin-based Nanosponges as a Vehicle for Antitumoral Drugs”, WO/003656 A1.
13. Guo L, Gao G, Liu X and Liu F,2008, “Preparation and characterization of TiO2 nanosponge”, Mater. Chem. Phys. 111, 322–325; DOI: 10.1186/1556- 276X-6-551
14. Wester R., Patel R., Natch S., Leyden J., Melendres J., and Maibach H, 1991. “Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy, J.Am. Acad. Derm;24: 720-726
15. Amber V, Shailendra S, Swarnalatha S. Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem, 2008; 62:23-42.
16. Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSciTech, 2005; 6(2):E329-E357.
17. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes –A Review. J Pharm Sci Tech, 2010; 2(3):171-183.
18. Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135.
19. Guo L, Gao G, Liu X and Liu F, 2008. “Preparation and characterization of TiO2 nanosponge”, Mater. Chem. Phys. 111, 322–325; DOI: 10.1186/1556- 276X-6-551.
20. Aritomi H, Yamasaki Y, Yamada K,Honda H and Khoshi M., 1996. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. Journal of Pharma Sci and Tech., 56(1):49-56.
21. Yurtdas G, Demirel M and Genc L,2011, “ Inclusion complexes of fluconazole with b-cyclodextrin: physicochemical char.cterization and in vitro evaluation of its formulation”, J. Incl. Phenom. Macrocycl. Chem. 70, 429–435; DOI: 10.1007/s10847-010-9908.
22. Poonam R, Prakash J, Priyanka S, Vivekkumar R, Nikita B, Varda J. A Comprehensive Review on Transdermal Delivery of Nanosponges. Asian Journal of Pharmaceutical Research and Development. 2023;11(4):126-132. DOI:/10.22270/ajprd.v11i4.1298
23. Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135.
24. Patel SB, Patel HJ and Seth AK, 2010. “Nanosponge Drug Delivery System: An Overview”, Journal of Global Pharma Tech., 2(8):1-9.
25. Nacht S, Kantz M, 1992. “The Microsponge: A Novel Topical Programmable Delivery System, In: Topical Drug Delivery Systems”, David WO, Anfon H A editors. New York: Marcel Dekker, 42;299- 325.sqd
26. Iravani S., Varma R.S. Nanosponges for Drug Delivery Applications. Nanomaterials, 2022
27. Selvamuthukumar S., et al. Nanosponges: A Novel Class of Drug Delivery system. J Pharm Sci.
28. Reddy J.R.K., et al. Recent Advances in Nanosponges. Next Nanotechnology 2026.