Recent Progress in Nanoemulsion–Loaded Herbal Creams for Enhanced Skin Delivery: A Comprehensive Review
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Abstract
Nanoemulsion formulations have emerged as an effective strategy to enhance the stability and bioavailability of hydrophobic drugs, particularly in cosmetic and dermatological applications. Owing to their small droplet size, nanoemulsions facilitate improved skin penetration and prolonged therapeutic action. This study presents an overview of herbal nanoemulsion-based delivery systems, emphasizing formulation techniques, preparation methods, and key characterization parameters such as particle size, polydispersity index (PDI), zeta potential, viscosity, and stability.
The present work focuses on the development of a polyherbal anti-acne formulation incorporating neem (Azadirachta indica) and aloe vera (Aloe barbadensis Miller), both known for their significant therapeutic properties. Neem contains bioactive compounds such as azadirachtin, nimbidin, and flavonoids, which exhibit potent antibacterial, antifungal, and antioxidant activities. Aloe vera is rich in polysaccharides, vitamins, and bioactive constituents that promote wound healing, hydration, and anti-inflammatory effects. The combination of these botanicals provides synergistic benefits in acne management by reducing microbial colonization, alleviating inflammation, and enhancing skin repair.
The formulated cream was evaluated for physicochemical parameters including pH, viscosity, spreadability, and stability, along with its antimicrobial activity against acne-causing microorganisms. The results indicated that the formulation possessed favorable consistency, acceptable pH, and significant antibacterial efficacy.
In conclusion, the developed herbal nanoemulsion-based formulation demonstrates potential as a safe, effective, and eco-friendly alternative to conventional synthetic treatments. Further studies involving clinical evaluation and large-scale production are recommended to support its commercialization and broader application in herbal skincare products.
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